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Epigenetic Therapies
Our laboratory is focused on the mechanisms by which epigenetic processes become misregulated in cancer and contribute to the disease phenotype. We focus on the role of DNA methylation in controlling the expression of genes during normal development and in cancer.
NEWS
In the Press
2 March 2018 Inside track: An epigenetics pioneer
Grand Rapids Business Journal
5 April 2017 Van Andel Institute installs world class microscope to help fight cancer
FOX 17
29 March 2017 VARI invests $10M in microscope facility
Grand Rapids Business Journal
24 Sept. 2015 Catalyzing Progress in Epigenetics Research
Cancer Research Catalyst – AACR
13 August 2015 Interview with Dr. Peter Jones on DNA methylation
The Naked Scientists
20 Oct. 2014 Van Andel Institute commits $7.5 million to Stand Up To Cancer “Dream Team” researching epigenetics
MLive
7 Oct. 2014 Fred Upton brings 21st Century Cures talks on fostering medical innovation to Kalamazoo
MLive
5 Sept. 2014 Grand Rapids scientist joins stars in Stand Up To Cancer telecast tonight
MLive
9 July 2014 Vision for Van Andel Institute: Lead scientist details plan for internationally known research center
MLive
25 Feb. 2014 VAI appoints world renowned doctor as director of research
WZZM
24 Feb. 2014 Van Andel Institute announces “historic moment” with plan for global epigenetics research hub
MLive
17 Dec. 2013 Van Andel Institute names CSO
Grand Rapids Business Journal
Featured Publications
Heblo AS et al. Nucleosome positioning and NDR structure at RNA polymerase III promoters. Sci Rep
Mundbjerg K et al. Identifying aggressive prostate cancer foci using a DNA methylation classifier. Genome Biol
Lakshminarasimhan R et al. Down-regulation of ARID1A is sufficient to initiate neoplastic transformation along with epigenetic reprogramming in non-tumorigenic endometriotic cells. Cancer Lett
Liu M et al. Vitamin C increases viral mimicry induced by 5-aza2’-deoxycytidine. Proc Natl Acad Sci U S A